Systemic and local elevation of LRG1 levels has been observed in patients with systemic diseases, such as diabetes mellitus and RA, suggesting a correlation with the pathology of the disease and demonstrating its effectiveness as a new diagnostic marker (Camilli et al., 2022; Fujimoto et al., 2015; Hong et al., 2019). This evidence concerns the gene LRG1 and rheumatoid arthritis.