Recent studies have shown that RIPK4 plays an important role in various cancers, exhibiting both oncogenic (Gong et al. 2018; Liu et al. 2015, 2018, 2021; Qi et al. 2018; Yi et al. 2020) and tumor suppressive (Kopparam et al. 2017; Li et al. 2021; Poligone et al. 2015; Wang et al. 2014) functions, depending on the cellular context. This evidence concerns the gene RIPK4 and neoplasm.