Outside of melanoma, a single study in head and neck squamous cell carcinoma reported on the prognostic utility of CD8+ TIL density derived using an image analysis algorithm in patients.28 However, upon multivariate modeling, CD8+ TIL density retained prognostic value only in HPV-negative tumors, and further, this study did not evaluate the value of CD8+ TIL density in predicting response to immunotherapy. Here, CD8A is linked to head and neck squamous cell carcinoma.