In addition, common genetic polymorphism at the IKZF1 locus have been associated with SLE susceptibility by GWAS (Cunninghame Graham et al., 2011), and one mechanism for this is an SLE-associated distal regulatory element required for normal expression of Ikaros in human T cells (Su et al., 2020). Here, IKZF1 is linked to systemic lupus erythematosus.