In the Abcb10 cKO mice, the gene expression of the mitochondrial disease biomarkers Gdf15 (growth differentiated factor 15) and Fgf21(fibroblast growth factor 21) gradually increased with age (Figure 2A), suggesting that mitochondrial dysfunction became progressively more severe as these mice aged. The gene discussed is GDF15; the disease is inborn mitochondrial metabolism disorder.