In the Abcb10 cKO mice, the gene expression of the mitochondrial disease biomarkers Gdf15 (growth differentiated factor 15) and Fgf21(fibroblast growth factor 21) gradually increased with age (Figure 2A), suggesting that mitochondrial dysfunction became progressively more severe as these mice aged. Here, ABCB10 is linked to inborn mitochondrial metabolism disorder.