VEGFB and cardiac hypertrophy: For this, we expressed the VEGF-B transgene as an autocrine ligand in the coronary endothelium, under the control of aP2 (adipocyte protein 2)/FABP4 (fatty acid binding protein 4) promoter,22 and compared its effects to those in the cardiomyocyte-specific paracrine model (αMHC-VEGF-B),12 with particular attention to coronary vessel growth and cardiac hypertrophy.