PRNP and Creutzfeldt Jacob disease: Creutzfeldt-Jakob disease (CJD), a rare but fatal neurodegenerative disorder, is caused by aggregation of misfolded protease-resistant prion protein scrapie (PrPSc) that derives from its normal cellular isoform (PrPC) in the brain (Hermann et al., 2021; Liao et al., 2021).