Inflammatory Bowel disease, a family history of CRC before age 60, hereditary polyposis (like Peutz‐Jegher syndrome and familial adenomatous polyposis, resulting from the mutation of an APC gene), LYNCH I, LYNCH II syndromes (nonpolyposis syndromes), and surveillance following CRC resection are a few examples of high risk population. This evidence concerns the gene APC and colorectal carcinoma.