A recent systematic review reported that the c-index in predicting severity of AP was 0.80 (95 % CI: 0.76–0.85) for CTSI, 0.79 (95 % CI: 0.72–0.86) for BISAP, 0.83 (95 % CI: 0.75–0.91) for mCTSI, 0.73 (95 % CI: 0.64–0.83) for CRP level, 0.81 (95 % CI: 0.75–0.87) for Ranson score, and 0.80 (95 % CI: 0.77–0.83) for APACHE II score [48]. The gene discussed is CRP; the disease is alkaline phosphatase measurement.