CFTR and cystic fibrosis: In the last 10 years, the care of patients with cystic fibrosis (CF) has been revolutionized with the introduction of <i>cystic fibrosis transmembrane conductance regulator</i> (CFTR) modulator drugs, with a major impact on symptoms and life expectancy, especially considering the newest and highly effective elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) therapy.