Some bypass tracks, like C-MET activation, Coactivation of MET and Proto-oncogene tyrosine-protein kinase Src (SRC), Yes-associated protein 1 (YAP 1), Amphiregulin, the overexpression of ATP-binding cassette subfamily C member 11 (ABCC11), Transformation to SCLC, and EMT, can cause alectinib-resistance as well (112, 114–118). The gene discussed is AREG; the disease is small cell lung carcinoma.