Our previous study found that if the OTR on mononuclear macrophages was conditionally knocked out in mice, the intestinal inflammation induced by DSS was more severe (Tang et al., 2019); Kara Gross Margolis et al. also found that necrotizing enterocolitis was further aggravated after pretreatment with atosiban, an inhibitor of OTR (Gross Margolis et al., 2017). This evidence concerns the gene OXTR and necrotizing enterocolitis.