SDC1 and neoplasm: Zhang and colleagues have found DNA methylation peaks in intragenic and intronic regions in bone marrow-derived CD138+ MM cells and found hypermethylation-mediated inhibition of tumor suppressors miRNA-10b-5p and miRNA-152, leading to overexpression of their target genes OGs DNMT1, BTRC, MYCBP, and E2F3 (137).