High mobility group protein B1 (HMGB1) is most typically linked to hypoxia-induced macrophage polarization.HMGB1 is overexpressed in numerous solid tumors and has been linked to skin carcinogenesis (66), inflammatory responses in hepatocellular carcinoma (67), and colon cancer (68). This evidence concerns the gene HMGB1 and malignant colon neoplasm.