Neurofibromatosis 1 (NF1) is a multisystem disorder characterized by café-au-lait spots of the skin, intertriginous freckling, multiple cutaneous neurofibromas, subcutaneous or deep nodular neurofibromas, plexiform neurofibromas, and characteristic ocular signs [36]. This evidence concerns the gene NF1 and neurofibromatosis type 1.