Neurofibromatosis 1 (NF1) is a multisystem disorder characterized by café-au-lait spots of the skin, intertriginous freckling, multiple cutaneous neurofibromas, subcutaneous or deep nodular neurofibromas, plexiform neurofibromas, and characteristic ocular signs [36]. The gene discussed is NF1; the disease is plexiform neurofibroma.