Moreover, silica-exposed macrophage exosomes express high levels of miR-7219-3p, which promotes fibroblast-to-myofibroblast trans-differentiation (FMT) and enhances silicosis-induced pulmonary fibrosis through Spouty1 (SPRY1) inhibition and extracellular signal-regulated protein kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway activation (Niu et al., 2022). The gene discussed is SPRY1; the disease is pulmonary fibrosis.