It has been discovered that WD repeat-containing 82 (WDR82) serves as the target gene for miR-501-3p, and its tumor-suppressive function has been demonstrated in rectal cancer (Liu et al., 2018; Li et al., 2021) Similarly, M2 macrophage-derived exosomes carrying miR-501-3p enhance lung cancer cell proliferation and invasion by downregulating WDR82 (76). The gene discussed is WDR82; the disease is rectal cancer.