For instance, the M2 macrophage-derived exosome AGAP2 antisense RNA 1 (AGAP2-AS1) promotes the malignant phenotype of radiation-resistant cancer cells by reducing the levels of miR-296 and increasing the expression of notch homolog protein 2 (NOTCH2) (Rao et al., 2022). The gene discussed is AGAP2; the disease is cancer.