For example, exosomes derived from M2 macrophages containing miR-1911-5p facilitate the migration and invasion of lung adenocarcinoma cells by silencing zinc finger and BTB domain-containing 4 (ZBTB4) (Guan et al., 2023), and ZBTB4 has been shown to regulate glycolipid metabolism and inhibit proliferation and invasion in malignancies such as pancreatic adenocarcinoma (Yang et al., 2023) and glioma (Dong et al., 2021). Here, ZBTB4 is linked to pancreatic adenocarcinoma.