Research has shown that a higher proportion of patients with early-onset cerebellar atrophy and ataxia carry variants in SNX14 (9.88%) compared to other known pathogenic genes such as GRID2 (2.47%), NPC1 (1.23%), and SETX (1.23%) (Akizu et al., 2015). Here, NPC1 is linked to Cerebellar atrophy.