INS and Insulin resistance: The homeostasis model assessment-insulin resistance (HOMA-IR) index, derived from fasting serum glucose and insulin, and the Triglyceride–Glucose (TyG) Index, derived from fasting blood glucose and triglycerides, are the most used indexes to estimate insulin resistance in clinical practice and can help to detect the obese at higher risk of having T2DM (52, 53).