It is plausible studies employing higher sensitivity platforms such as single-molecular array or Simoa (69) might better detect differences among MS subgroups, yet this is not requisite given mean CSF NfL levels in MS studies typically range from 800 to 2,200 pg./mL vs. 250–550 pg./mL in controls (67). The gene discussed is NEFL; the disease is myeloid sarcoma.