The level of Sox2, a transcription factor that is a persistent marker for multipotential neural stem cells, showed a significant decrease in hNPCs-OE of MDD and BPD cells compared with the control group (q=3.027, p=0.007; q=2.92, p=0.01; H=10.63, d.f. = 2, p=0.005; Figure 2B.1). The gene discussed is SOX2; the disease is major depressive disorder.