IL6 and major depressive disorder: There is less certainty about the role of IL-8 in BDP; in one study, a lower association was found between the genetic expression of IL-8 compared to IL-6 with dissociative symptoms in BPD (46); in another study, similar concentrations were found of IL-8 in young women with MDD comorbid with BPD when compared to a healthy comparator group (47).