Through its binding activity, PXR can modulate downstream gene expression, influencing various processes such as detoxification, metabolism, inflammation inhibition, cell apoptosis, tumor migration, and antioxidant stress.[22, 25] The effects of PXR in diseases such as drug‐induced liver injury and cancer are multifaceted, exhibiting both positive and negative effects depending on the context. The gene discussed is NR1I2; the disease is cancer.