Positive effects include detoxification, anti‐inflammatory and anti‐apoptotic effects, and lifespan extension,[26] while negative effects involve increased expression of drug‐metabolizing enzymes leading to reactive metabolite formation, hyperglycemia, lipid accumulation, and steatosis.[27] In this study, we demonstrated that activation of PXR effectively alleviates hepatic oxidative stress and apoptosis induced by xenobiotic DON, highlighting the crucial role of targeting PXR activation in combating xenobiotic pollution and enhancing hepatic antioxidant capacity. Here, NR1I2 is linked to steatosis.