Some researchers have also revealed how downregulation of NDUFS1, the largest subunit of ubiquinone oxidoreductase (complex 1) in the mitochondrial electron transport chain, promotes malignant progression of gastric cancer by activating the mROS-HIF1α-FBLN5 signaling pathway, emphasizing the critical role of targeting the mitochondrial components in gastric cancer therapy [13]. The gene discussed is HIF1A; the disease is gastric cancer.