Additionally, genomic mutations are also implicated in this process, supported by identified mutations in Neurogenic Locus Notch Homolog Protein (NOTCH) 2, NOTCH1, and Phosphatase and Tensin Homolog (PTEN) in HCV-positive diffuse large B cell lymphoma (DLBCL) patients [10]. This evidence concerns the gene NOTCH2 and diffuse large B-cell lymphoma.