GEN1 and congenital anomaly of kidney and urinary tract: In our previous studies, Gen1 PB insertion mice developed phenotypes consistent with human CAKUT phenotypes; Gen1PB/PB mice demonstrated reduced Gen1 expression (down to 15%) and a CAKUT incidence of 50%, while Gen1PB/+ mice demonstrated a less severe reduction in Gen1 expression (down to 60%) and a CAKUT incidence of 20% [35].