In conclusion, epigenetic modifications promotes or inhibits pyroptosis of tumor cells by regulating DNA methylation, RNA methylation and histone modification of key pyroptosis-related proteins such as caspase-1, caspase-3, GSDMA/B/D/E, NLRP1 and NLRP3, which in turn affects the regulation of tumor progression and drug resistance. This evidence concerns the gene CASP3 and neoplasm.