Interestingly, up-regulation of H3K4me1 and H3K27Ac promotes lncRNA LINC00969 expression in NSCLC cells, then LINC00969 interacts with METTL3 and inhibits NLRP3 in an m6A-YTHDF2-dependent manner to inhibit pyroptosis in NSCLC, thereby promoting drug resistance of NSCLC [85]. This evidence concerns the gene NLRP3 and non-small cell lung carcinoma.