Interestingly, hypoxia inhibits METTL14 expression in a HIF-1α-dependent manner, which in turn reduces m6A methylation of the SLC7A11 mRNA 5’UTR in HCC and up-regulates SLC7A11 expression via the YTHDF2 pathway to inhibit ferroptosis in HCC [101]. This evidence concerns the gene YTHDF2 and hepatocellular carcinoma.