As an illustration, research by Diwakar Davar and colleagues [139] revealed that responder-derived fecal microbiota transplant (R-FMT) combined with pembrolizumab could enhance the induction of CD8 + T cells, decrease IL-8 synthesis, and bolster the immune responses against tumor cells resistant to anti-PD-1 [139, 140]. Here, CD8A is linked to neoplasm.