Casp8 induces PD-L1 ubiquitination and promotes its degradation by upregulating TNFAIP3 (A20) expression in murine melanoma, suggesting that reduced Casp8 expression may serve as a potential biomarker for predicting sensitivity to anti-PD-L1 immunotherapies [43, 44]. This evidence concerns the gene TNFAIP3 and melanoma.