Innovative therapies include HHAT and APT1/2 inhibitors and 2-bromopalmitate (2-BP) in polymer-lipid hybrid nanoparticles (2-BP/CPT-PLNs) that replace anti-PD-L1 antibodies in immune checkpoint blockade, showing potent antitumor effects and improved survival in melanoma models [197–199]. This evidence concerns the gene CD274 and melanoma.