HLA-B and toxic epidermal necrolysis: Our study, we found the specific association of HLA-B*58:01 allele and allopurinol-induced cADRs (OR = 137.2, P-value = 1.7 × 10− 27), SJS-TEN (OR = 582.0, P-value = 3.7 × 10− 23), DRESS (OR = 92.2, P-value = 2.3 × 10− 14) and MPE (OR = 63.7, P-value = 2.7 × 10− 6) in Thai population.