As described in Table 3, rs9263733 (POLR2LP) was the most significantly associated SNP with allopurinol-induced SJS/TEN, with an OR of 395.2 (95% CI 49.0–16306.3; P-value = 7.1 × 10− 20). This evidence concerns the gene POLR2LP1 and toxic epidermal necrolysis.