Some genes are widespread in chondrocyte 4, and chondrocyte 5 may play an important role in the process of lumbar disc degeneration together with the Wnt/Ca2+signaling pathway, such as ANGPTL4, PTGES, IGFBP3, GDF15, TRIB3, and TNFRSF10B. Here, GDF15 is linked to lumbar disk degenerative disorder.