Firstly, it triggers a complex intracellular signaling milieu comprising activities of hypoxia-inducible factors (HIFs), phosphoinositide 3-kinase-AKT kinase/mammalian target of rapamycin (PI3K-AKT/mTOR), mitogen activated protein kinases (MAPK), nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways that promote tumor cells survival, aggressiveness, invasion and resistance to therapy [6, 7]. This evidence concerns the gene PIK3CA and neoplasm.