STAT3 and neoplasm: Conversely, loss of STAT3 suppressed expression of all evaluated hypoxia and EMT markers in glioblastoma cell line as well as in analyzed tumor originating from these cells with notable exception of HIF1a and VEGFC. Collectively, these results seem to suggest that loss of STAT3 at least in the present model does not render cells more chemosensitive to TMZ nor does it act suppressively on tumor growth in vivo.