The main findings of this study were as follows: (1) MetS aggravated LV deformation and functional damage in OCAD patients, especially the LV GLPS; (2) for OCAD patients, MetS was found to be an independent factor of impaired LV GLPS and increased LVM; (3) the ROC analysis suggested that MetS increased the prediction efficiency of decreased LV GLPS and increased LVM; (4) the degree of coronary stenosis was higher in patients with OCAD comorbid with MetS; and (5) the impaired LV GLPS and increased LVM also had an independent correlation with NT-proBNP in OCAD patients. The gene discussed is NPPB; the disease is coronary stenosis.