RPS6KB1 and colorectal adenocarcinoma: Using Caco−2 human colorectal adenocarcinoma cells, we showed that HIF1-alpha may alleviate LPS-induced intestinal epithelial model in vitro.HIF−1α attenuated LPS-induced Caco−2 cell injury by upregulating structural protein expression and decreasing permeability; additionally, HIF−1α alleviated LPS-induced Caco−2 injury, a process that might be regulated by mTOR/P70S6K signalling.