CPQ and neoplasm: In contrast, we also evaluated the cell cycle distribution in Trop2+ tumor cell lines treated with different concentrations of hIMB1636-LDP-AE and observed a significant decrease in G1 DNA content and an increase in G2 DNA content in a concentration-dependent manner, not only in HCC827 and H1975 cells (Fig. 6c, d) but also in MDA-MB-468 and MCF-7 cells (Fig. 6e, f).