The results indicated that CD45 on HLA DR + CD8br, BAFF-R on IgD + CD38dim and BAFF-R on B cell are common risk factors for osteonecrosis and drug-induced osteonecrosis, while HLA DR on CD33br HLA DR + CD14dim serves as a common protective feature for both (Fig. 5). Here, TNFRSF13C is linked to osteonecrosis.