Immunofluorescence and western blots on cerulein-induced pancreatitis samples from pancreatic acinar cell-specific Kras knock-in (Ptf1aCreERTM; LSL-KrasG12D) and functional WT Ptf1aCreERTM mouse lines mimicking AP and CP to allow for in vivo confirmation. This evidence concerns the gene KRAS and alkaline phosphatase measurement.