Previous studies of non-inherited EOCRCs have described an enrichment of pathogenic variants in TP53 and CTNNB1 and losses of heterozygosity (LOH) at chromosomes 17p and 18q, with relatively low prevalences of mutations in KRAS, BRAF, and in additional tumor suppressor genes and oncogenes that occur in CRC of older patients7,15,16. Here, TP53 is linked to colorectal carcinoma.