Interestingly, CCNF was positively correlated with the infiltration abundance of activated NK cells, TNK cells, Tfh cells, Tregs, and MDSCs, the high expression of which predicted poor survival in KIRC-TCGA patients, while it was negatively correlated with resting memory CD4 + T cells, activated mast cells, and HSCs that conferred a better prognosis when present in tumor microenvironment. This evidence concerns the gene CCNF and neoplasm.