FGFR2 and maturity-onset diabetes of the young: Notably, after FGFR was blocked by inhibitors, pancreas dysfunction-related pathways, such as the age-rage-signaling pathway, which is involved in diabetic complications, maturity-onset diabetes of the young (MODY), and pancreatic secretion, were found to be enriched in differentially expressed genes after blockade of the FGF7-FGFR2 signaling pathway (Fig. 2l).