To induce colonic epithelial ulceration and inflammation, Cldn-7fl/fl;Lgr5-CreERT2 and Cldn-7fl/fl;Lgr5-CreW mice were treated with 2%DSS for 7 days to induce acute colitis, followed by normal drinking water for 14 days to observe the repair of intestinal injury. Here, LGR5 is linked to colitis.