Moreover, the mRNA level of the other well studied deacetylase SIRT3 was further tested and the result indicated that, consistent with the reduced expression of Sirt1, the mRNA level of Sirt3 was also significantly decreased in diabetic oocytes, which might be another mechanism for the meiosis disorder and the elevated oxidative stress level in diabetic oocytes [3, 4]. This evidence concerns the gene SIRT1 and meiotic cell cycle.