Our results showed that H4K16ac signals were increased in oocytes of the mouse with diabetes partially due to the decreased expression of Sirt1, while NMN supplementation could decrease the H4K16ac signals in oocytes of the mouse with diabetes, which was further confirmed by the fact that the NMN treatment increased expression of Sirt1. Abnormal H3K4 methylation has been observed in the maternal aging oocytes and postovulatory aging oocytes [58, 59]. Here, SIRT1 is linked to diabetes mellitus.