Several tumor microenvironment (TME) features, such as expression of PD-L1 (ref. 17) and presence of CD8+ T cells in tumors18, were demonstrated to be predictive of response to PD-1/PD-L1 inhibitors in some cancer types; however, their predictive value in dMMR gynecologic cancers is unknown. The gene discussed is CD8A; the disease is cancer.