The protein EWS1 (Ewing’s sarcoma breakpoint region 1) along with the gene products encoded by FUS (fused in sarcoma)/TLS (translocated in liposarcoma) and the TATA box binding associated factor 15 (Taf15), are RNA and DNA binding proteins that belong to the FET (FUS, EWS, TAF15) family of proteins [84]. The gene discussed is EWSR1; the disease is sarcoma.