Genome-wide association studies (GWAS) of neuroblastoma have identified over a dozen susceptibility loci and these genetic associations have implicated genes such as CASC15, NBAT1, BARD1, LMO1, DUSP12, DDX4, IL31RA, HSD17B12, HACE1, LIN28B, TP53, RSRC1, MLF1, CPZ, MMP20, KIF15, and NBPF2328–37. The gene discussed is HSD17B12; the disease is neuroblastoma.