In Lotus, the epidermal Nod factor receptor NFRe aids the symbiosis initiated by NFR1 and NFR5, enabling optimal signaling and symbiosis establishment40, while the Chitinase Chit5 cleaves bacterial Nod factors, maintaining an optimal level of signaling during infection which is necessary for infection thread progression inside nodule primordia41. This evidence concerns the gene OVGP1 and infection.