The involvement of SOX9 in oncogenesis, chemoresistance, and stem cell maintenance in cancers highlights its critical regulatory functions in tumor biology.12 YAP and SOX9 are aberrantly upregulated in many tumors, where they serve as critical regulators driving tumor progress.13,14 YAP transcriptionally promotes SOX9 expression in the development of several tumors,15,16 whereas the role and mechanism of SOX9 in the regulation of YAP activity remains controversial. The gene discussed is SOX9; the disease is cancer.