VGLL4 and neoplasm: For instance, verteporfin (a porphyrin compound) blocked the YAP-TEAD interaction and suppressed ovarian cancer growth in mice.47 Similarly, a rationally engineered ‘super-TDU’ peptide derived from VGLL4, which specifically disrupts the YAP-TEAD interaction, has been shown to effectively halt the progression of gastric cancer.48 In light of this, impeding YAP nuclear localization directed by SOX9 emerges as another strategy to inhibit YAP activity and subsequently suppress tumor growth.