The upregulation of YAP and SOX9 has been observed across a range of tumor types, but the precise functional relationship between these two factors remains controversial in various tissues or cells.15–18 It has been reported that YAP transcriptionally upregulates the expression of SOX9 in hepatocyte-derived progenitor cells, indicating a potential synergistic relationship between them.36 Conversely, Liu et al. discovered that SOX9 is required for YAP-induced hepatocyte plasticity during hepatocarcinogenesis in mice. Here, SOX9 is linked to neoplasm.