Whileadditional investigation is necessary to identify the primary cellularresponders to SLR-LNPs and to further examine their immunopharmacologicaleffects on the tumor and secondary lymphoid tissues, their abilityto remodel the TME to increase CD8+ and CD4+ T-cell infiltration also offers exciting opportunities for the furtherdevelopment of combination immune receptors to enhance therapeuticresponses. Here, CD8A is linked to neoplasm.