TLR4 and gout: In terms of genetics, there are many pathways involved in regulating or influencing the development of gout, such as the Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammatory route, Toll-like receptor 4 (TLR4)/MyD88 signaling system, and TLR4-NF-κB signaling pathway.