A cytokine storm is a hyperinflammatory response to an infection caused by a sudden spike in levels of pro-inflammatory cytokines and chemokines, including IL-1, IL-2, IL-4, IL-6, IL-7, IL-8, IL9, IL-10, IL-18, granulocyte stimulating factor (G-CSF), IP-10, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage inflammatory protein 1 (MIP-1A), cutaneous T-cell attracting chemokine (CTACK), IFN-γ, and TNF-α. The gene discussed is CCL27; the disease is infection.