Our MR study suggest that GroEL antibodies not only increase the risk of T2DM, but also raise blood glucose levels, which is similar with the findings of Ningning You et al. on H. pylori and blood glucose [27], who demonstrated that H. pylori infection is a distinct risk factor for elevated blood glucose levels in nondiabetic individuals, and that persistent H. pylori infection leads to elevated fasting plasma glucose and TG/HDL levels, which give rise to the development of T2DM. Here, HSPD1 is linked to type 2 diabetes mellitus.