Functional pathway enrichment analysis of this set of DEGs suggested that ES neurons in the PD-LBD brain microenvironment not only exhibited more extensive deregulation of dopaminergic synaptic functions but also revealed more obvious signs of mitochondrial hyperactivity [73,74] (e.g., oxidative phosphorylation and proton transmembrane transport), stress-induced senescence responses (e.g., oncogene-induced senescence and transcriptional regulation by TP53), and iron-related toxicity (e.g., iron update and transport) (S20G Fig). This evidence concerns the gene TP53 and Parkinson disease.