However, while no significant associations were found between the overall cell number ratio and patient APOE status (S15 Fig) or neuropathological changes (e.g., Braak or CERAD) (S16 and S17 Figs), the specific cell number ratio of ES neurons was consistently correlated with definitive diagnostic status (e.g., AD, Figs 4F and S18) or severity of cognitive decline (e.g., higher Cogdx scores, Figs 4G and S19). This evidence concerns the gene APOE and Mental deterioration.