With reference to the matching trend of changes observed in previously reported AD-related CNV loci [12], including those found to be gained (e.g., SDF4, BIN1, ERMP1, and VDLR) (S13A Fig) and lost in AD (e.g., SLC30A3, DNAJC5G, TRIM54, KLK6, HAS, and FPR1) (S13B and S13C Fig), which validates our approach, an additional set of differentially expressed AD risk genes was identified. The gene discussed is SDF4; the disease is Alzheimer disease.